Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813777 | 0.84 | KIF11 (0.50) | PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL9025037 | 0.81 | PTGS2 (0.53) | PTGS2PTGS1AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL444872 | 0.80 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL7938542 | 0.80 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL7938041 | 0.79 | PTGS2 (0.55) | PTGS2PTGS1 | |
| Water SCHEMBL27918427 | 0.78 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL20703304 | 0.77 | SMN1; SMN2 (0.50) | — | |
| SCHEMBL4015306 | 0.75 | KCNN4 (0.50) | — | |
| SCHEMBL6470141 | 0.74 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL7938593 | 0.74 | PTGS2 (0.62) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |