Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 6/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.40 |
| ▸ | C1R | P00736 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586547 | 0.81 | ALDH1A1 (0.44) | HSD11B1CYP1A2CYP3A4TDP1ALDH1A1 | |
| SCHEMBL2062896 | 0.81 | DCUN1D1 (0.44) | HSD17B10TDP1ALDH1A1POLBNPSR1 | |
| SCHEMBL28770634 | 0.81 | DCUN1D1 (0.44) | TRPA1TRPM8TRPV1ALDH1A1POLB | |
| SCHEMBL15329526 | 0.78 | PARP1 (0.40) | HSD11B1PARP1TRPA1TRPM8C1R | |
| SCHEMBL31521761 | 0.78 | GABRA1 (0.42) | TRPA1PTGESPOLBNPSR1 | |
| SCHEMBL649565 | 0.77 | HPGD (0.56) | CYP1A2MAPK1HSD17B10ALDH1A1POLB | |
| SCHEMBL2060891 | 0.75 | GUSB (0.46) | C1RTDP1ALDH1A1PTGESPOLB | |
| SCHEMBL31314834 | 0.74 | PDE5A (0.33) | POLBNPSR1 | |
| SCHEMBL11695271 | 0.74 | TDO2 (0.46) | SCN9APOLBNPSR1 | |
| SCHEMBL11623789 | 0.74 | HPGD (0.43) | HSD17B10ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772600-A1 | 1,2-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003388-A1 | 1,2-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |