Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | POLB | P06746 | 4/20 | 0.63 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | BCHE | P06276 | 1/20 | 0.63 |
| ▸ | MPO | P05164 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | ALPL | P05186 | 1/20 | 0.60 |
| ▸ | ALPG | P10696 | 1/20 | 0.60 |
| ▸ | GCGR | P47871 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8425964 | 0.89 | SMN1; SMN2 (0.79) | KMT2ASMN1; SMN2HPGDMEN1HCRTR1 | |
| SCHEMBL14304382 | 0.87 | KMT2A (0.79) | KMT2ASMN1; SMN2HPGDMEN1HCRTR1 | |
| SCHEMBL8251328 | 0.86 | KMT2A (0.77) | KMT2ASMN1; SMN2HPGDMEN1MAPT | |
| SCHEMBL29770390 | 0.86 | KMT2A (1.00) | KMT2ASMN1; SMN2HPGDMEN1NPC1 | |
| SCHEMBL3515244 | 0.86 | KMT2A (1.00) | KMT2ASMN1; SMN2HPGDMEN1NPC1 | |
| SCHEMBL15474114 | 0.84 | KMT2A (0.75) | KMT2ASMN1; SMN2HPGDMEN1HCRTR1 | |
| SCHEMBL11269102 | 0.84 | POLB (0.72) | KMT2ASMN1; SMN2HPGDMAPTPOLB | |
| SCHEMBL11116603 | 0.84 | KMT2A (0.69) | KMT2ASMN1; SMN2HPGDMAPTPOLB | |
| SCHEMBL16256659 | 0.84 | KMT2A (0.69) | KMT2ASMN1; SMN2HPGDMEN1HCRTR1 | |
| SCHEMBL10762447 | 0.83 | KMT2A (0.73) | KMT2ASMN1; SMN2HPGDMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2014-09-18 | — | — | US | disclosed |
| EP-0485423-B1 | PROCESS FOR THE PRODUCTION OF PYRAZOLO(1,5-a)BENZIMIDAZOLE COUPLERS | KODAK LTD (GB) | 1997-01-29 | — | — | EP | disclosed |
| US-5210209-A | Reacting 2-amino- or 2-mercaptobenzimidazole to triazepinone or thiadiazine, ring contracting to 2-methylpyrazolobenzimidazole, removing substituents at 3 and 4 positions | EASTMAN KODAK COMPANY (US) | 1993-05-11 | — | — | US | disclosed |
| EP-0485423-A1 | PYRAZOLO(1,5-a)BENZIMIDAZOLE COUPLERS. | KODAK LTD (GB) | 1992-05-20 | — | — | EP | disclosed |
| WO-1991001984-A1 | PYRAZOLO(1,5-a)BENZIMIDAZOLE COUPLERS | EASTMAN KODAK COMPANY (US) | 1991-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | CDA, DCTD, ADA | KMT2A 1471/4885SMN1; SMN2 2561/4885HPGD 1501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.