Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.79 |
| ▸ | HPGD | P15428 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | BCHE | P06276 | 1/20 | 0.69 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 9/20 | 0.64 |
| ▸ | NPC1 | O15118 | 8/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | AR | P10275 | 1/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.59 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797365 | 0.89 | KMT2A (0.75) | SMN1; SMN2HPGDKMT2ABCHEEPHX2 | |
| SCHEMBL14304382 | 0.85 | KMT2A (0.79) | SMN1; SMN2HPGDKMT2ABCHEEPHX2 | |
| SCHEMBL29770390 | 0.83 | KMT2A (1.00) | SMN1; SMN2HPGDKMT2ABCHEEPHX2 | |
| SCHEMBL3515244 | 0.83 | KMT2A (1.00) | SMN1; SMN2HPGDKMT2ABCHEEPHX2 | |
| SCHEMBL8251328 | 0.83 | KMT2A (0.77) | SMN1; SMN2HPGDKMT2ABCHEEPHX2 | |
| SCHEMBL11269102 | 0.82 | POLB (0.72) | SMN1; SMN2HPGDKMT2APOLBTDP1 | |
| SCHEMBL7298254 | 0.82 | EPHX2 (0.75) | SMN1; SMN2HPGDKMT2ABCHEEPHX2 | |
| SCHEMBL7998438 | 0.82 | BCHE (0.73) | SMN1; SMN2HPGDKMT2ABCHEEPHX2 | |
| SCHEMBL31175737 | 0.82 | BCHE (0.73) | SMN1; SMN2HPGDKMT2ABCHEEPHX2 | |
| SCHEMBL15474114 | 0.82 | KMT2A (0.75) | SMN1; SMN2HPGDKMT2ABCHEEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942641-A | TREATMENT OF ALZHEIMER'S DISEASE, NERVOUS SYSTEM DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-24 | — | — | US | disclosed |
| EP-0655992-B1 | FLUORENONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CENTRAL OR PERIPHERAL NERVE DEGENERATION REPAIR AND PROTECTIVE AGENT | OTSUKA PHARMA CO LTD (JP) | 1998-11-04 | — | — | EP | disclosed |
| EP-0791570-A1 | Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-27 | — | — | EP | disclosed |
| EP-0655992-A1 | FLUORENONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CENTRAL OR PERIPHERAL NERVE DEGENERATION REPAIR AND PROTECTIVE AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-06-07 | — | — | EP | disclosed |
| WO-1995000468-A1 | FLUORENONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CENTRAL OR PERIPHERAL NERVE DEGENERATION REPAIR AND PROTECTIVE AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-01-05 | — | — | WO | disclosed |