Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.45 |
| ▸ | EDNRB | P24530 | 2/20 | 0.39 |
| ▸ | EDNRA | P25101 | 2/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798759 | 0.87 | LPAR1 (0.41) | LPAR1SOAT1MAPTP2RX7ALDH1A1 | |
| SCHEMBL8797939 | 0.86 | LMNA (0.47) | MAPTALDH1A1HTTMEN1TP53 | |
| SCHEMBL8797398 | 0.85 | LPAR1 (0.49) | LPAR1EDNRBEDNRASOAT1SHMT2 | |
| SCHEMBL8797672 | 0.82 | EDNRB (0.46) | EDNRBEDNRASHMT2MAPTP2RX7 | |
| SCHEMBL10699642 | 0.76 | EDNRB (0.41) | EDNRBEDNRAMAPTP2RX7ALDH1A1 | |
| SCHEMBL8797644 | 0.73 | GRM1 (0.45) | SOAT1MAPTALDH1A1HTTMEN1 | |
| SCHEMBL10702160 | 0.73 | HTR2B (0.40) | EDNRBEDNRAMAPTP2RX7ALDH1A1 | |
| SCHEMBL8798165 | 0.73 | TBXAS1 (0.41) | LPAR1ROCK2MEN1TP53KMT2A | |
| SCHEMBL8615128 | 0.73 | LPAR1 (0.48) | LPAR1EDNRBEDNRASOAT1 | |
| SCHEMBL8797272 | 0.72 | TP53 (0.45) | LPAR1MAPTTP53KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |