Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.46 |
| ▸ | EDNRA | P25101 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699642 | 0.84 | EDNRB (0.41) | EDNRBEDNRAP2RX7ALDH1A1DRD2 | |
| SCHEMBL8798118 | 0.82 | DRD2 (0.35) | EDNRBEDNRAP2RX7DRD2DRD3 | |
| SCHEMBL8797397 | 0.82 | ALDH1A1 (0.49) | EDNRBEDNRAALDH1A1DRD2DRD3 | |
| SCHEMBL8797372 | 0.82 | LPAR1 (0.45) | EDNRBEDNRAP2RX7ALDH1A1SHMT2 | |
| SCHEMBL8797476 | 0.81 | MAPT (0.43) | P2RX7ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL10702160 | 0.81 | HTR2B (0.40) | EDNRBEDNRAP2RX7ALDH1A1DRD2 | |
| SCHEMBL8800043 | 0.78 | DRD2 (0.36) | EDNRBEDNRAP2RX7ALDH1A1DRD2 | |
| SCHEMBL7209964 | 0.77 | EDNRB (0.36) | EDNRBEDNRAP2RX7ALDH1A1DRD2 | |
| SCHEMBL7615965 | 0.75 | HTR1A (0.35) | EDNRBEDNRAP2RX7ALDH1A1DRD2 | |
| Fumaric Acid SCHEMBL29896602 | 0.74 | CYP1A2 (0.36) | EDNRBEDNRAP2RX7ALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |