Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 2/20 | 0.64 |
| ▸ | CHRNG | P07510 | 2/20 | 0.64 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.64 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.64 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.64 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.64 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.64 |
| ▸ | CHRND | Q07001 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | DBH | P09172 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL633275 | 0.87 | CHRNA1 (0.62) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL15822168 | 0.85 | KDM4E (0.53) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL12332226 | 0.83 | CHRNA1 (0.58) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL3670046 | 0.82 | KDM4E (0.59) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL16357740 | 0.80 | CHRNA1 (0.55) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL27581493 | 0.79 | HTT (0.53) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL11666862 | 0.79 | GAA (0.52) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL17275631 | 0.79 | GAA (0.52) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL769448 | 0.79 | SLC6A3 (1.00) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL172415 | 0.78 | KDM4E (0.71) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070244096-A1 | Fused Bicyclic Nitrogen-Containing Heterocycles | JAPAN TOBACCO INC. (JP) | 2007-10-18 | — | — | US | disclosed |
| US-20070244096-A1 | Fused Bicyclic Nitrogen-Containing Heterocycles | JAPAN TOBACCO INC. (JP) | 2007-10-18 | — | — | US | disclosed |
| US-7244727-B2 | Fused bicyclic nitrogen-containing heterocycles | JAPAN TOBACCO INC. (JP) | 2007-07-17 | — | — | US | disclosed |
| US-7244727-B2 | Fused bicyclic nitrogen-containing heterocycles | JAPAN TOBACCO INC. (JP) | 2007-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244096-A1 | Fused Bicyclic Nitrogen-Containing Heterocycles | PC, HCCS, MYC | CHRNA1 4687/4885CHRNG 4425/4885CHRNB1 4596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.