Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.58 |
| ▸ | DRD3 | P35462 | 7/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 8/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | HTR6 | P50406 | 3/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | DRD5 | P21918 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797503 | 0.97 | DRD2 (0.61) | DRD2DRD3ADRA1AHRH4HTR7 | |
| SCHEMBL8797848 | 0.94 | HTR7 (0.53) | DRD2DRD3ADRA1AHRH4HTR7 | |
| SCHEMBL8798070 | 0.84 | DRD2 (0.54) | DRD2DRD3ADRA1AHRH4HTR7 | |
| SCHEMBL8798032 | 0.84 | DRD2 (0.60) | DRD2DRD3ADRA1AHRH4HTR7 | |
| SCHEMBL8797545 | 0.84 | KCNH2 (0.60) | DRD2HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL13532761 | 0.83 | DRD2 (0.61) | DRD2DRD3ADRA1AHRH4HTR7 | |
| SCHEMBL13532766 | 0.81 | HTR2A (0.60) | DRD2DRD3ADRA1AHTR7HTR1A | |
| SCHEMBL8798171 | 0.79 | DRD2 (0.52) | DRD2DRD3ADRA1AHRH4HTR7 | |
| SCHEMBL1781126 | 0.79 | TSHR (0.58) | DRD2HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL13532745 | 0.78 | DRD2 (0.60) | DRD2DRD3ADRA1AHRH4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707571-B1 | 3,5-DIOXO-(2H,4H)-1,2,4-TRIAZINE DERIVATIVES AS 5HT1A LIGANDS | PF MEDICAMENT (FR) | 1997-05-02 | — | — | EP | claimed |
| US-5591743-A | ANXIOLYTIC DRUGS OR HYPOTENSIVE AGENTS | PIERRE FABRE MEDICAMENT (FR) | 1997-01-07 | — | — | US | claimed |
| EP-0707571-A1 | 3,5-DIOXO-(2H,4H)-1,2,4-TRIAZINE DERIVATIVES AS 5HT1A LIGANDS | PF MEDICAMENT (FR) | 1996-04-24 | — | — | EP | claimed |
| WO-1995001965-A1 | 3,5-DIOXO-(2H,4H)-1,2,4-TRIAZINE DERIVATIVES AS 5HT1A LIGANDS | PIERRE FABRE MEDICAMENT (FR) | 1995-01-19 | — | — | WO | claimed |
| US-5591743-A | ANXIOLYTIC DRUGS OR HYPOTENSIVE AGENTS | PIERRE FABRE MEDICAMENT (FR) | 1997-01-07 | — | — | US | disclosed |