Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798009 | 0.91 | ALDH1A1 (0.31) | HTR2AHTR2CHRH1GAA | |
| SCHEMBL8797964 | 0.83 | HTR2A (0.34) | HTR2AHTR2CHRH1 | |
| SCHEMBL8797817 | 0.79 | ALDH1A1 (0.31) | SLC6A2SLC6A4 | |
| SCHEMBL10446931 | 0.79 | HTR2A (0.35) | HTR2AHTR2CHRH1CYP2D6SLC6A2 | |
| SCHEMBL19334942 | 0.79 | HTR2A (0.35) | HTR2AHTR2CHRH1CYP2D6SLC6A2 | |
| SCHEMBL10444651 | 0.75 | HTR2A (0.38) | HTR2AHTR2CHRH1CYP2D6SLC6A2 | |
| SCHEMBL8797797 | 0.75 | IMPDH2 (0.36) | HTR2AHTR2CHRH1CYP2D6SLC6A2 | |
| SCHEMBL8799249 | 0.75 | ALDH1A1 (0.40) | HTR2AHTR2CHRH1 | |
| SCHEMBL7522168 | 0.74 | MAPT (0.38) | HTR2AHTR2CHRH1CYP2D6SLC6A2 | |
| SCHEMBL7526416 | 0.73 | HTR2A (0.40) | HTR2AHTR2CHRH1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |