Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | G6PD | P11413 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9037166 | 0.80 | POLB (0.39) | POLBADORA3KDM4EALDH1A1MAPT | |
| SCHEMBL9036984 | 0.76 | GRIA1 (0.56) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL9037382 | 0.75 | GRIA1 (0.50) | ADORA3ALDH1A1MEN1KMT2APARP1 | |
| SCHEMBL9040060 | 0.75 | GRIA1 (0.50) | ADORA3ALDH1A1PARP1 | |
| SCHEMBL11326239 | 0.75 | KMT2A (0.53) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL30273075 | 0.75 | ADORA3 (0.52) | POLBADORA3KDM4EALDH1A1MAPT | |
| SCHEMBL30567506 | 0.74 | ALDH1A1 (0.42) | POLBADORA3KDM4EALDH1A1MAPT | |
| SCHEMBL30273081 | 0.71 | POLB (1.00) | POLBADORA3KDM4EALDH1A1MAPT | |
| SCHEMBL1599006 | 0.71 | POLB (1.00) | POLBADORA3KDM4EALDH1A1MAPT | |
| SCHEMBL9038023 | 0.71 | GRIA1 (0.50) | MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153196-A | Administering for reduction of neurotransmission in nervous system disorders | ELI LILLY AND COMPANY (US) | 1992-10-06 | — | — | US | claimed |
| WO-2016024096-A1 | ANTIBACTERIAL COMPOUNDS | REDX PHARMA PLC (GB) | 2016-02-18 | — | — | WO | disclosed |
| EP-0708778-B1 | IMIDAZO[1,2-A]PYRAZIN-4-ONE DERIVATIVES FOR USE AS AMPA AND NMDA RECEPTOR ANTAGONISTS | RHONE POULENC RORER SA (FR) | 1997-02-05 | — | — | EP | disclosed |
| EP-0518530-B1 | Improvements in or relating to excitatory amino acid receptor antagonists | LILLY CO ELI (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5196421-A | Treatment of neurological disorders | ELI LILLY AND COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0518530-A2 | Improvements in or relating to excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1992-12-16 | — | — | EP | disclosed |
| US-5153196-A | Administering for reduction of neurotransmission in nervous system disorders | ELI LILLY AND COMPANY (US) | 1992-10-06 | — | — | US | disclosed |