Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797254 | 0.86 | NLRP3 (0.36) | TP53NLRP3LPAR1MAPK1LMNA | |
| SCHEMBL8797727 | 0.86 | TP53 (0.49) | TP53NLRP3LPAR1LMNAKMT2A | |
| SCHEMBL8797534 | 0.85 | NLRP3 (0.39) | TP53NLRP3LPAR1MAPK1LMNA | |
| SCHEMBL8797400 | 0.85 | NLRP3 (0.39) | NLRP3LPAR1MAPK1LMNAKMT2A | |
| SCHEMBL8797236 | 0.85 | LPAR1 (0.43) | NLRP3LPAR1MAPK1LMNAKMT2A | |
| SCHEMBL8798206 | 0.82 | NLRP3 (0.37) | NLRP3LPAR1MAPK1LMNAKMT2A | |
| SCHEMBL8797985 | 0.82 | NLRP3 (0.35) | NLRP3LPAR1MAPK1LMNAKMT2A | |
| SCHEMBL8797723 | 0.80 | LPAR1 (0.44) | NLRP3LPAR1MAPK1LMNAKMT2A | |
| SCHEMBL8797373 | 0.80 | LPAR1 (0.44) | NLRP3LPAR1MAPK1LMNAKMT2A | |
| SCHEMBL8798116 | 0.79 | TBXAS1 (0.39) | NLRP3LPAR1MAPK1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | claimed |