Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.32 |
| ▸ | NAAA | Q02083 | 3/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327502 | 0.95 | METAP2 (0.39) | METAP2CTSSCTSKMETAP1MMP2 | |
| SCHEMBL8323683 | 0.89 | METAP2 (0.39) | METAP2CTSSCTSKMETAP1 | |
| Potassium Ion SCHEMBL8798428 | 0.86 | METAP2 (0.36) | METAP2CTSSCTSKMETAP1EPHX1 | |
| SCHEMBL8328926 | 0.85 | METAP2 (0.38) | METAP2CTSSCTSKMETAP1 | |
| SCHEMBL8798969 | 0.82 | CASP1 (0.34) | METAP2CTSSCTSKEPHX1FKBP1A | |
| SCHEMBL8331769 | 0.80 | EPHX1 (0.44) | METAP2CTSSCTSKEPHX1 | |
| SCHEMBL8800052 | 0.78 | METAP2 (0.38) | METAP2METAP1 | |
| SCHEMBL8329953 | 0.76 | METAP2 (0.37) | METAP2CTSSCTSKEPHX1 | |
| SCHEMBL8800115 | 0.76 | METAP2 (0.37) | METAP2CTSSCTSKEPHX1 | |
| SCHEMBL8798756 | 0.75 | METAP2 (0.36) | METAP2CTSSCTSKMMP2BMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792878-A2 | Geminal carboxylic acids and esters thereof, pharmaceutical formulations containing them useful in the treatment of bone dysmetabolism | Dompé S.P.A. (IT) | 1997-09-03 | — | — | EP | disclosed |