Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Veliflapon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Veliflapon SCHEMBL1004174 | 1.00 | ALOX5 (1.00) | ALOX5HDAC6 | |
| Veliflapon SCHEMBL29405516 | 1.00 | ALOX5 (1.00) | ALOX5HDAC6 | |
| Veliflapon SCHEMBL502932 | 1.00 | ALOX5 (1.00) | ALOX5HDAC6 | |
| Veliflapon SCHEMBL30386644 | 1.00 | ALOX5 (1.00) | ALOX5HDAC6 | |
| SCHEMBL2109295 | 0.99 | ALOX5 (1.00) | ALOX5HDAC6 | |
| SCHEMBL2110833 | 0.99 | ALOX5 (1.00) | ALOX5HDAC6 | |
| SCHEMBL7818529 | 0.99 | ALOX5 (1.00) | ALOX5HDAC6 | |
| SCHEMBL9123409 | 0.99 | ALOX5 (1.00) | ALOX5HDAC6 | |
| SCHEMBL9123415 | 0.99 | ALOX5 (1.00) | ALOX5HDAC6 | |
| SCHEMBL7818344 | 0.99 | ALOX5 (1.00) | ALOX5HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8245593-A | — | — | None | — | — | JP | disclosed |
| JP-8253448-A | — | — | None | — | — | JP | disclosed |
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| JP-H08253448-A | HETEROCYCLIC SUBSTITUENT GROUP-CONTAINING OXY-PHENYL(PHENYL)GLYCINOL AMIDE | BAYER AG | 1996-10-01 | — | — | JP | disclosed |
| JP-H08245593-A | 4-(QUINOLIN-2-YL-METHOXY)-PHENYL-ACETIC ACID DERIVATIVE | BAYER AG | 1996-09-24 | — | — | JP | disclosed |
| US-5512581-A | ANTIINFLAMMATORY AGENT | ABBOTT LABORATORIES (US) | 1996-04-30 | — | — | US | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |