Veliflapon

Veliflapon

SCHEMBL1004174

O=C(O)[C@@H](c1ccc(OCc2ccc3ccccc3n2)cc1)C1CCCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ALOX5AP

The experimentally established mechanism targets of Veliflapon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 20/20 1.00
HDAC6 Q9UBN7 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Veliflapon SCHEMBL29405516 1.00 ALOX5 (1.00) ALOX5HDAC6
Veliflapon SCHEMBL502932 1.00 ALOX5 (1.00) ALOX5HDAC6
Veliflapon SCHEMBL8798993 1.00 ALOX5 (1.00) ALOX5HDAC6
Veliflapon SCHEMBL30386644 1.00 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL2109295 0.99 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL2110833 0.99 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL7818529 0.99 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL9123409 0.99 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL9123415 0.99 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL7818344 0.99 ALOX5 (1.00) ALOX5HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 629 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4482481-B1 COMPOUNDS FOR USE IN THE TREATMENT OF DYSTROPHINOPATHIES SOM INNOVATION BIOTECH S A (ES) 2025-11-12 EP claimed
US-20250152567-A1 COMPOUNDS FOR USE IN THE TREATMENT OF DYSTROPHINOPATHIES REGENTS OF THE UNIVERSITY OF MINNESOTA 2025-05-15 US claimed
EP-4482481-A1 COMPOUNDS FOR USE IN THE TREATMENT OF DYSTROPHINOPATHIES Som Innovation Biotech, S.L. (ES) 2025-01-01 EP claimed
WO-2023156645-A1 COMPOUNDS FOR USE IN THE TREATMENT OF DYSTROPHINOPATHIES SOM INNOVATION BIOTECH, S.A. (ES) 2023-08-24 WO claimed
EP-4230196-A1 COMPOUNDS FOR USE IN THE TREATMENT OF DYSTROPHINOPATHIES Som Innovation Biotech, S.A. (ES) 2023-08-23 EP claimed
WO-2023075715-A1 A PHARMACEUTICAL FORMULATION INCLUDING LEUKOTRIENE RECEPTOR ANTAGONISTS AND/OR LEUKOTRIENE SYNTHESIS INHIBITORS COMBINED WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) VSY BIYOTEKNOLOJI VE ILAC SANAYI ANONIM SIRKETI (TR) 2023-05-04 WO claimed
EP-3126004-A1 METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISORDERS Rogne Bioscience Inc. (US) 2017-02-08 EP claimed
WO-2015153838-A1 METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISORDERS ROGNE BIOSCIENCE INC. (US) 2015-10-08 WO claimed
US-8980918-B2 Amorphous (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-acetic acid ATOPIX THERAPEUTICS LIMITED (GB) 2015-03-17 US claimed
US-8703956-B2 Amorphous (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-acetic acid ATOPIX THERAPEUTICS LIMITED (GB) 2014-04-22 US claimed
US-20060019269-A1 Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment DECODE GENETICS, INC. (IE) 2006-01-26 US claimed
EP-1579010-A2 SUSCEPTIBILITY GENE FOR MYOCARDIAL INFARCTION; METHODS OF TREATMENT Decode Genetics EHF. (IS) 2005-09-28 EP claimed
WO-2005075022-A2 SUSCEPTIBILITY GENE FOR MYOCARDIAL INFRACTION, STROKE, AND PAOD; METHODS OF TREATMENT DECODE GENETICS EHF. (IS) 2005-08-18 WO claimed
WO-2004035741-A2 SUSCEPTIBILITY GENE FOR MYOCARDIAL INFARCTION; METHODS OF TREATMENT DECODE GENETICS EHF. (IS) 2004-04-29 WO claimed
US-6342510-B1 ANTIINFLAMMATORY AGENTS AND ENZYME INHIBITORS G. D. SEARLE & CO. 2002-01-29 US claimed
WO-2001034199-A2 ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER ELI LILLY AND COMPANY (US) 2001-05-17 WO claimed
EP-0637961-A4 METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE WITH LEUKOTRIENE SYNTHESIS INHIBITORS. MILES INC (US) 1995-08-09 EP claimed
US-5391555-A Administering 2-(4(2-quinolinyl-methoxy)-phenyl)-acetic acid derivatives; Crohn's disease MILES INC. (US) 1995-02-21 US claimed
EP-0637961-A1 METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE WITH LEUKOTRIENE SYNTHESIS INHIBITORS Bayer Corporation (US) 1995-02-15 EP claimed
WO-1994018976-A1 METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE WITH LEUKOTRIENE SYNTHESIS INHIBITORS MILES INC. (US) 1994-09-01 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250152567-A1 COMPOUNDS FOR USE IN THE TREATMENT OF DYSTROPHINOPATHIES MTPN, UTRN, TTN ALOX5 2322/4885HDAC6 767/4885
US-20060019269-A1 Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment PLAAT3, PLAAT2, PLA2G7 ALOX5 13/4885HDAC6 4187/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.