Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870485 | 0.88 | NPC1 (0.52) | LMNAMAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL8799866 | 0.88 | CES2 (0.51) | LMNAMAPTNPC1RAB9ACES2 | |
| SCHEMBL27532250 | 0.87 | MAPT (0.51) | LMNAMAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL27903906 | 0.84 | HTT (0.56) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL4746226 | 0.81 | SMN1; SMN2 (0.50) | LMNAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL5704292 | 0.81 | RAB9A (0.62) | LMNAMAPTNPC1RAB9ACES2 | |
| SCHEMBL5242291 | 0.80 | PARP1 (0.51) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL29972427 | 0.79 | CES2 (0.67) | LMNAMAPTRAB9ACES2CES1 | |
| SCHEMBL27888985 | 0.78 | MAPT (0.51) | LMNAMAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL978349 | 0.78 | NPC1 (0.49) | MAPTNPC1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772601-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |