Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | HTR5A | P47898 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798735 | 0.86 | PDE3B (0.41) | PDE3BPDE3AMEN1KMT2APOLB | |
| SCHEMBL9685732 | 0.74 | LTA4H (0.42) | PDE3BPDE3AALDH1A1KDM4E | |
| SCHEMBL9484787 | 0.72 | ALDH1A1 (0.37) | PDE3BPDE3AMEN1KMT2AMAPK1 | |
| SCHEMBL9483334 | 0.72 | ALDH1A1 (0.48) | MEN1KMT2AMAPK1ALDH1A1MAPT | |
| SCHEMBL11698216 | 0.67 | PDE3B (0.49) | PDE3BPDE3AHTR5AMEN1KMT2A | |
| SCHEMBL7647136 | 0.67 | PDE3B (0.49) | PDE3BPDE3AHTR5AMEN1KMT2A | |
| SCHEMBL20551035 | 0.67 | NOX1 (0.50) | HTR5AMEN1KMT2APOLBMAPK1 | |
| SCHEMBL18916808 | 0.65 | KCNH2 (0.49) | PDE3BPDE3AHSD17B10TSHRBCL2 | |
| SCHEMBL28960338 | 0.63 | PDE3B (0.41) | PDE3BPDE3AHTR5AMEN1KMT2A | |
| SCHEMBL29242101 | 0.62 | SNCA (0.63) | PDE3BPDE3AHTR5AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506539-B1 | Heterocyclic alkylamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-05-02 | — | — | EP | disclosed |
| US-5436348-A | Sleep disorders | ADIR ET COMPAGNIE (FR) | 1995-07-25 | — | — | US | disclosed |
| US-5386034-A | Treatment of sleeping, psychological and nervous system disorders; anxiolytic agents, ovulation regulators | ADIR ET COMPAGNIE (FR) | 1995-01-31 | — | — | US | disclosed |
| US-5326775-A | Treating sleep disorders | ADIR ET COMPAGNIE (FR) | 1994-07-05 | — | — | US | disclosed |
| US-5322843-A | Treating sleep disorders | ADIR ET COMPAGNIE (FR) | 1994-06-21 | — | — | US | disclosed |
| US-5322849-A | Treating sleep disorders | ADIR ET COMPAGNIE (FR) | 1994-06-21 | — | — | US | disclosed |
| US-5300507-A | Treating sleep disorders | ADIR ET COMPAGNIE (FR) | 1994-04-05 | — | — | US | disclosed |
| US-5240919-A | Treating sleep disorders | ADIR ET COMPAGNIE (FR) | 1993-08-31 | — | — | US | disclosed |
| EP-0506539-A1 | Heterocyclic alkylamides, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-09-30 | — | — | EP | disclosed |