SCHEMBL8799268

SCHEMBL8799268

CCOCn1c(-c2ccc(C(F)(F)F)cc2)c(Br)c(C(F)(F)F)c1C(F)(F)F

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 1/20 0.32
KIF11 P52732 1/20 0.31
PDE2A O00408 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8799002 0.89 MEN1 (0.34)
SCHEMBL8797802 0.83 SLC6A3 (0.32)
SCHEMBL5813013 0.81 KIF11 (0.35) MAPK14KIF11
SCHEMBL9220849 0.76 MAPK14 (0.33) MAPK14
SCHEMBL9567356 0.76 KIF11 (0.33) KIF11
SCHEMBL5819960 0.73 KIF11 (0.35) MAPK14KIF11
SCHEMBL9389300 0.73
SCHEMBL9257392 0.72 MEN1 (0.35) MAPK14
SCHEMBL17552422 0.71
SCHEMBL28742523 0.71 MAPK14 (0.37) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0481182-B1 Bis- and tris(trifluoromethyl) arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID CO (US) 1997-01-29 EP claimed
US-5157047-A Miticides AMERICAN CYANAMID COMPANY (US) 1992-10-20 US claimed
EP-0481182-A1 Bis- and tris(trifluoromethyl) arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID COMPANY (US) 1992-04-22 EP claimed