SCHEMBL8799290

SCHEMBL8799290

O=C1CN(S(=O)(=O)c2cc3ccc(Cl)cc3s2)C(=O)N1

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.47
F2 P00734 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8799136 0.90 F10 (0.39) F10F2
SCHEMBL5953051 0.83 CA2 (0.49) F10
SCHEMBL27574290 0.78 PKM (0.60) F10F2
SCHEMBL8798949 0.77 CA2 (0.34)
SCHEMBL8799786 0.76 HDAC3 (0.37)
SCHEMBL8799201 0.76 HDAC3 (0.37)
SCHEMBL8973357 0.76 MEN1 (0.51) F10
SCHEMBL8973126 0.75 MEN1 (0.50) F10
SCHEMBL8797869 0.74 POLB (0.43) F10
SCHEMBL8799158 0.74 CMA1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0355827-B1 Hydantoin derivatives MOCHIDA PHARM CO LTD (JP) 1997-01-02 EP disclosed
EP-0444546-B1 Hydantoin derivatives for use as hypoglycemic and/or hypolipidemic agents MOCHIDA PHARM CO LTD (JP) 1996-09-11 EP disclosed
US-RE35279-E ALDOSE REDUCTASE INHIBITORS MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1996-06-18 US disclosed
US-5202339-A Hypoglycemic, hypolipedemic agents MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1993-04-13 US disclosed
WO-1991012803-A1 HYDANTOIN DERIVATIVES FOR USE AS HYPOGLYCEMIC AND/OR HYPOLIPIDEMIC AGENTS MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1991-09-05 WO disclosed
EP-0444546-A1 Hydantoin derivatives for use as hypoglycemic and/or hypolipidemic agents MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1991-09-04 EP disclosed
US-5004751-A Antidiabetic agents; aldoe reductase inhibitors MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1991-04-02 US disclosed
WO-1990002126-A1 HYDANTOIN DERIVATIVES MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1990-03-08 WO disclosed
EP-0355827-A2 Hydantoin derivatives MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1990-02-28 EP disclosed