Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 8/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800299 | 0.92 | LTB4R (0.50) | LTB4RLTB4R2ALDH1A1LMNADHODH | |
| SCHEMBL8799655 | 0.91 | LTB4R (0.44) | LTB4RLTB4R2ALDH1A1LMNADHODH | |
| SCHEMBL8799232 | 0.84 | CYP4A11 (0.51) | LTB4RLTB4R2ALDH1A1LMNAHDAC1 | |
| SCHEMBL9122731 | 0.83 | LTB4R (0.48) | LTB4RLTB4R2ALDH1A1HDAC1HDAC6 | |
| SCHEMBL8463994 | 0.83 | LTB4R (0.54) | LTB4RLTB4R2 | |
| SCHEMBL8799275 | 0.83 | CYP4F2 (0.57) | LTB4RLTB4R2ALDH1A1CYP4F2CYP4A11 | |
| SCHEMBL8799314 | 0.82 | LTB4R (0.49) | LTB4RLTB4R2ALDH1A1LMNAHDAC1 | |
| SCHEMBL9119413 | 0.82 | LTB4R (0.58) | LTB4RLTB4R2 | |
| SCHEMBL9121586 | 0.82 | LTB4R (0.58) | LTB4RLTB4R2 | |
| SCHEMBL9121682 | 0.82 | LTB4R (0.58) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |