Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 8/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799308 | 0.91 | LTB4R (0.45) | LTB4RLTB4R2ALDH1A1LMNAHDAC1 | |
| SCHEMBL8799422 | 0.86 | MAPT (0.50) | LTB4RLTB4R2ALDH1A1LMNAHDAC1 | |
| SCHEMBL8798860 | 0.84 | CYP4F2 (0.46) | LTB4RLTB4R2ALDH1A1LMNAFOLH1 | |
| SCHEMBL8800299 | 0.82 | LTB4R (0.50) | LTB4RLTB4R2ALDH1A1LMNAHDAC1 | |
| SCHEMBL8799314 | 0.82 | LTB4R (0.49) | LTB4RLTB4R2ALDH1A1LMNAHDAC1 | |
| SCHEMBL8799248 | 0.79 | LTB4R (0.67) | LTB4RLTB4R2 | |
| SCHEMBL8799461 | 0.79 | LTB4R (0.48) | LTB4RLTB4R2ALDH1A1LMNAHDAC1 | |
| SCHEMBL8800182 | 0.78 | LTB4R (0.47) | LTB4RLTB4R2 | |
| SCHEMBL8799232 | 0.78 | CYP4A11 (0.51) | LTB4RLTB4R2ALDH1A1LMNAHDAC1 | |
| SCHEMBL8798506 | 0.78 | LTB4R (0.49) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |