Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 12/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800299 | 0.91 | LTB4R (0.50) | LTB4RLTB4R2ALDH1A1LMNAPPARD | |
| SCHEMBL8464377 | 0.88 | LTB4R (0.53) | LTB4RLTB4R2PPARDCYP2C9MAPT | |
| SCHEMBL6760695 | 0.87 | LTB4R (0.57) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL8799461 | 0.86 | LTB4R (0.48) | LTB4RLTB4R2ALDH1A1LMNAPPARD | |
| SCHEMBL8799635 | 0.84 | CYP4F2 (0.49) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL8799308 | 0.82 | LTB4R (0.45) | LTB4RLTB4R2ALDH1A1LMNAHDAC1 | |
| SCHEMBL8799655 | 0.82 | LTB4R (0.44) | LTB4RLTB4R2ALDH1A1LMNAHDAC1 | |
| SCHEMBL8799585 | 0.81 | LTB4R (0.43) | LTB4RLTB4R2 | |
| SCHEMBL8799535 | 0.80 | LTB4R (0.70) | LTB4RLTB4R2 | |
| SCHEMBL8463994 | 0.78 | LTB4R (0.54) | LTB4RLTB4R2PPARDCYP2C9CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |