Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSPO | P30536 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799665 | 0.91 | ALDH1A1 (0.38) | ALDH1A1LMNATSPOHTTTP53 | |
| SCHEMBL8799244 | 0.85 | MAPT (0.47) | ALDH1A1LMNAHTTTP53KDM4E | |
| SCHEMBL9122739 | 0.82 | PPARD (0.44) | ALDH1A1FOLH1KDM4EKMT2A | |
| SCHEMBL8463998 | 0.81 | PPARG (0.48) | ALDH1A1FOLH1SMN1; SMN2 | |
| SCHEMBL8799325 | 0.81 | ALDH1A1 (0.41) | ALDH1A1LMNAHTTFOLH1KDM4E | |
| SCHEMBL8799259 | 0.80 | LTB4R (0.52) | — | |
| SCHEMBL9119193 | 0.80 | PPARG (0.53) | ALDH1A1FOLH1 | |
| SCHEMBL9119992 | 0.80 | PPARG (0.53) | ALDH1A1FOLH1 | |
| SCHEMBL8799004 | 0.80 | PPARG (0.38) | ALDH1A1FOLH1KDM4EHPGD | |
| SCHEMBL9121693 | 0.80 | PPARG (0.53) | ALDH1A1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |