Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.44 |
| ▸ | FDFT1 | P37268 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727045 | 0.85 | FDFT1 (0.43) | ADRB2ADRB1FDFT1MEN1KMT2A | |
| SCHEMBL8564876 | 0.80 | KDM4E (0.49) | FDFT1ALDH1A1LPAR1MAPT | |
| SCHEMBL8564882 | 0.80 | KDM4E (0.49) | FDFT1ALDH1A1LPAR1MAPT | |
| SCHEMBL8799234 | 0.79 | FDFT1 (0.42) | ADRB2ADRB1FDFT1IDO1CYP2D6 | |
| SCHEMBL8118267 | 0.78 | FDFT1 (0.48) | ADRB2ADRB1FDFT1CYP2D6NFKB1 | |
| SCHEMBL14364963 | 0.76 | MEN1 (0.42) | MEN1KMT2AALDH1A1LPAR1IDO1 | |
| SCHEMBL6956611 | 0.75 | FDFT1 (0.41) | ADRB2ADRB1FDFT1CYP2D6NFKB1 | |
| SCHEMBL6957617 | 0.74 | KDM4E (0.44) | FDFT1MEN1KMT2AALDH1A1LPAR1 | |
| SCHEMBL6956071 | 0.74 | FDFT1 (0.52) | FDFT1CNR1 | |
| SCHEMBL3255465 | 0.73 | RECQL (0.46) | FDFT1MEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5677298-A | USEFUL FOR THE PROPHYLAXIS OR THERAPY OF HYPERCHOLESTEREMIA OR CORONOARY SCLEROSIS OF MAMMALS | TAKEDA CHEMICAL INDUSTRIES (JP) | 1997-10-14 | — | — | US | disclosed |
| EP-0645377-B1 | Benzoxazepine derivatives useful as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-08-13 | — | — | EP | disclosed |
| EP-0645377-A1 | Benzoxazepine derivatives useful as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-03-29 | — | — | EP | disclosed |