Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 9/20 | 0.52 |
| ▸ | CNR1 | P21554 | 6/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799234 | 0.76 | FDFT1 (0.42) | FDFT1 | |
| SCHEMBL7340285 | 0.76 | MAPK1 (0.49) | CNR1CNR2EPHX1EPHX2NPC1 | |
| SCHEMBL8118267 | 0.75 | FDFT1 (0.48) | FDFT1 | |
| SCHEMBL6956611 | 0.75 | FDFT1 (0.41) | FDFT1 | |
| SCHEMBL8799319 | 0.74 | ADRB2 (0.44) | FDFT1CNR1 | |
| SCHEMBL9727045 | 0.74 | FDFT1 (0.43) | FDFT1CNR1 | |
| SCHEMBL10886234 | 0.73 | EBP (0.50) | CXCR4EPHX1NPC1RAB9A | |
| SCHEMBL8564882 | 0.69 | KDM4E (0.49) | FDFT1EPHX1NPC1RAB9A | |
| SCHEMBL8564876 | 0.69 | KDM4E (0.49) | FDFT1EPHX1NPC1RAB9A | |
| SCHEMBL11168379 | 0.69 | KDM4E (0.59) | CNR1CNR2EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567026-B1 | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |
| EP-0567026-A1 | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-27 | — | — | EP | disclosed |