Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.44 |
| ▸ | FDFT1 | P37268 | 3/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564882 | 0.83 | KDM4E (0.49) | KDM4EFDFT1LPAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8564876 | 0.83 | KDM4E (0.49) | KDM4EFDFT1LPAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17661872 | 0.78 | PDK1 (0.50) | PDK1PDK2PDK3PDK4LPAR1 | |
| SCHEMBL6956611 | 0.78 | FDFT1 (0.41) | KDM4EFDFT1 | |
| SCHEMBL9727045 | 0.76 | FDFT1 (0.43) | KDM4EFDFT1LPAR1ALDH1A1MEN1 | |
| SCHEMBL4113798 | 0.76 | GRIK1 (0.47) | KDM4EALDH1A1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL28091743 | 0.76 | PDK1 (0.69) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL1139376 | 0.74 | PDK1 (0.51) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL8799319 | 0.74 | ADRB2 (0.44) | FDFT1LPAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL4118333 | 0.74 | LPAR1 (0.53) | KDM4EPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567026-B1 | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-5885979-A | SQUALENE SYNTHETASE INHIBITOR TREATING OR PREVENTING HYPERLIPIDEMIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-23 | — | — | US | disclosed |
| US-5726306-A | INHIBITORS OF SQUALENE SYNTHETASE AND FUNGAL GROWTH; USEFUL IN TREATING AND PREVENTING HYPERLIPIDEMIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-10 | — | — | US | disclosed |
| EP-0567026-A1 | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-27 | — | — | EP | disclosed |