Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL943416 | 0.84 | KCNH2 (0.52) | KCNH2HRH1KDM1ARCOR1MEN1 | |
| SCHEMBL16252558 | 0.82 | NAMPT (0.52) | KDM1ARCOR1MEN1KMT2AALDH1A1 | |
| SCHEMBL11954000 | 0.82 | GPR119 (0.48) | KDM1ARCOR1MEN1KMT2AALDH1A1 | |
| SCHEMBL8799456 | 0.81 | HRH3 (0.49) | KCNH2HRH1MTNR1BHRH3 | |
| Hydrochloric Acid SCHEMBL9013839 | 0.80 | HRH3 (0.49) | KCNH2KDM1ARCOR1HRH3 | |
| SCHEMBL4764984 | 0.78 | NAMPT (0.56) | — | |
| SCHEMBL12070796 | 0.78 | HRH1 (0.54) | KCNH2HRH1KDM1ARCOR1HRH3 | |
| SCHEMBL6156469 | 0.78 | EPHX1 (0.54) | KCNH2HRH1 | |
| SCHEMBL8800051 | 0.76 | ALDH1A1 (0.54) | KCNH2MTNR1BALDH1A1HRH3 | |
| SCHEMBL15030362 | 0.76 | HRH1 (0.59) | KCNH2HRH1KDM1ARCOR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635505-B1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GMBH (DE) | 1997-10-15 | — | — | EP | disclosed |
| US-5561145-A | 4-aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) | 1996-10-01 | — | — | US | disclosed |
| EP-0635505-A1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GmbH (DE) | 1995-01-25 | — | — | EP | disclosed |