Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800051 | 0.87 | ALDH1A1 (0.54) | HRH3KCNH2L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL13652530 | 0.86 | HRH3 (0.56) | HRH3 | |
| SCHEMBL943416 | 0.84 | KCNH2 (0.52) | KCNH2HRH1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9013839 | 0.82 | HRH3 (0.49) | HRH3KCNH2 | |
| SCHEMBL18596083 | 0.82 | HRH3 (0.57) | HRH3SMN1; SMN2 | |
| SCHEMBL8799332 | 0.81 | KCNH2 (0.49) | HRH3KCNH2HRH1MTNR1B | |
| SCHEMBL5662169 | 0.78 | NAMPT (0.56) | SMN1; SMN2 | |
| Fumaric Acid SCHEMBL9013889 | 0.78 | RAB9A (0.50) | HRH3KCNH2HRH1HPGD | |
| SCHEMBL17534841 | 0.78 | HRH3 (0.72) | HRH3SMN1; SMN2HPGD | |
| SCHEMBL14684839 | 0.78 | HRH1 (0.54) | HRH3KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635505-B1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GMBH (DE) | 1997-10-15 | — | — | EP | disclosed |
| US-5561145-A | 4-aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) | 1996-10-01 | — | — | US | disclosed |
| EP-0635505-A1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GmbH (DE) | 1995-01-25 | — | — | EP | disclosed |