Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314604 | 0.75 | EGFR (0.53) | EGFRGRM1 | |
| SCHEMBL8319476 | 0.75 | EGFR (0.45) | EGFRKDR | |
| SCHEMBL19634086 | 0.75 | EGFR (0.58) | EGFRKDRGRM1FBP1 | |
| SCHEMBL392194 | 0.75 | GPR119 (0.65) | EGFR | |
| SCHEMBL13177645 | 0.74 | EGFR (0.57) | EGFRKDR | |
| SCHEMBL4718772 | 0.73 | GPR119 (0.51) | EGFRKDR | |
| SCHEMBL8799034 | 0.71 | KCNH2 (0.52) | EGFRKDRFBP1 | |
| SCHEMBL8799037 | 0.71 | KCNH2 (0.52) | EGFRKDRFBP1 | |
| SCHEMBL8317623 | 0.71 | EGFR (0.54) | EGFRGRM1FBP1 | |
| SCHEMBL7000121 | 0.70 | KCNH2 (0.51) | EGFRKDRGRM1MAPK1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |