Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 5/20 | 0.61 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.61 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799650 | 0.88 | CYP4F2 (0.46) | CYP4A11CYP4F2DHODHSLC7A5LOXL2 | |
| SCHEMBL8800306 | 0.84 | ALDH1A1 (0.44) | CYP4A11CYP4F2DHODHALDH1A1KDM4E | |
| SCHEMBL31752933 | 0.80 | CYP4A11 (0.97) | CYP4A11CYP4F2DHODHSLC7A5LOXL2 | |
| SCHEMBL9122184 | 0.79 | CYP4F2 (0.36) | CYP4A11CYP4F2 | |
| SCHEMBL18540811 | 0.78 | CYP4A11 (1.00) | CYP4A11CYP4F2DHODHSLC7A5LOXL2 | |
| SCHEMBL8800020 | 0.77 | CYP4F2 (0.40) | CYP4A11CYP4F2ALDH1A1MAPTRAB9A | |
| SCHEMBL9121580 | 0.76 | CYP4F2 (0.47) | CYP4A11CYP4F2SLC7A5FOLH1RAB9A | |
| SCHEMBL5663990 | 0.75 | CYP4A11 (0.91) | CYP4A11CYP4F2DHODHSLC7A5LOXL2 | |
| SCHEMBL9122509 | 0.74 | ALDH1A1 (0.45) | ALDH1A1RAB9A | |
| SCHEMBL8799399 | 0.73 | CYP4A11 (0.61) | CYP4A11CYP4F2DHODHLOXL2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |