SCHEMBL8800306

SCHEMBL8800306

COC(=O)c1ccccc1CCCOC(Cc1ccccc1CCCCCCO)C(=O)OC

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
LMNA P02545 3/20 0.44
DHODH Q02127 1/20 0.42
CYP4A11 Q02928 4/20 0.40
CYP4F2 P78329 3/20 0.40
KDM4E B2RXH2 2/20 0.36
GLA P06280 1/20 0.36
SLC16A3 O15427 3/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C19 P33261 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TSHR P16473 2/20 0.35
SCN1A P35498 2/20 0.34
SCN2A Q99250 2/20 0.34
SCN3A Q9NY46 2/20 0.34
HIF1A Q16665 1/20 0.34
POLB P06746 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8799468 0.87 ALDH1A1 (0.43) ALDH1A1LMNADHODHKDM4ESLC16A3
SCHEMBL9122184 0.84 CYP4F2 (0.36) CYP4A11CYP4F2
SCHEMBL8799411 0.84 CYP4A11 (0.61) ALDH1A1DHODHCYP4A11CYP4F2KDM4E
SCHEMBL5253878 0.82 ALDH1A1 (0.62) ALDH1A1LMNADHODHCYP4A11CYP4F2
SCHEMBL2655008 0.82 ALDH1A1 (0.62) ALDH1A1LMNADHODHCYP4A11CYP4F2
SCHEMBL3554041 0.81 ALDH1A1 (0.64) ALDH1A1LMNADHODHCYP4A11CYP4F2
SCHEMBL8799592 0.81 MEN1 (0.42) ALDH1A1LMNAKDM4ESMN1; SMN2HPGD
SCHEMBL383349 0.77 ALDH1A1 (0.66) ALDH1A1LMNADHODHCYP4A11CYP4F2
SCHEMBL8801665 0.77 ALDH1A1 (0.43) ALDH1A1LMNADHODHCYP4A11CYP4F2
SCHEMBL8799587 0.75 CYP4F2 (0.43) CYP4A11CYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0755381-A1 SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 1997-01-29 EP disclosed
WO-1995028386-A1 SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 1995-10-26 WO disclosed