Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | P2RY10 | O00398 | 3/20 | 0.35 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119398 | 0.88 | CYP4F2 (0.45) | PPARGCYP4F2CYP4A11DHFRPPARA | |
| SCHEMBL9118405 | 0.82 | CYP4F2 (0.40) | PPARGCYP4F2CYP4A11PPARALTB4R | |
| SCHEMBL8802031 | 0.82 | CYP4F2 (0.40) | PPARGCYP4F2CYP4A11PPARALTB4R | |
| SCHEMBL8799349 | 0.82 | CYP4F2 (0.40) | PPARGCYP4F2CYP4A11PPARALTB4R | |
| SCHEMBL8800173 | 0.82 | CYP4F2 (0.40) | PPARGCYP4F2CYP4A11PPARALTB4R | |
| SCHEMBL8800010 | 0.82 | CYP4F2 (0.40) | PPARGCYP4F2CYP4A11PPARALTB4R | |
| SCHEMBL8466647 | 0.81 | CYP4F2 (0.37) | PPARGCYP4F2CYP4A11PPARALTB4R | |
| SCHEMBL8799756 | 0.78 | PPARG (0.44) | PPARGCYP4F2CYP4A11DHFRPPARA | |
| SCHEMBL9121439 | 0.76 | MEN1 (0.43) | PPARGPPARAPPARDALDH1A1 | |
| SCHEMBL9118208 | 0.75 | PTGS2 (0.33) | PPARGCYP4F2CYP4A11PPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |