Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | P2RY10 | O00398 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799767 | 0.88 | PPARG (0.40) | CYP4F2CYP4A11PPARGDHFRPPARA | |
| SCHEMBL6757565 | 0.86 | PPARG (0.37) | PPARGPPARALTB4RLTB4R2PPARD | |
| SCHEMBL17670843 | 0.79 | CYP4F2 (0.66) | CYP4F2CYP4A11PPARGDHFRLTB4R | |
| SCHEMBL9121594 | 0.78 | PPARG (0.53) | PPARGPPARALTB4RLTB4R2PPARD | |
| SCHEMBL9119423 | 0.78 | PPARG (0.53) | PPARGPPARALTB4RLTB4R2PPARD | |
| SCHEMBL9119193 | 0.78 | PPARG (0.53) | PPARGPPARALTB4RLTB4R2PPARD | |
| SCHEMBL9119992 | 0.78 | PPARG (0.53) | PPARGPPARALTB4RLTB4R2PPARD | |
| SCHEMBL9121693 | 0.78 | PPARG (0.53) | PPARGPPARALTB4RLTB4R2PPARD | |
| SCHEMBL9123303 | 0.77 | LTB4R (0.64) | PPARGLTB4RLTB4R2ALDH1A1 | |
| SCHEMBL6755952 | 0.77 | ALDH1A1 (0.43) | PPARGLTB4RLTB4R2PPARDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |