Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801068 | 0.81 | GPR84 (0.51) | GPR84ALDH1A1MEN1LMNAMAPT | |
| SCHEMBL9486575 | 0.76 | CYP19A1 (0.49) | CYP19A1ALDH1A1MEN1LMNAMAPT | |
| SCHEMBL8802605 | 0.76 | CYP19A1 (0.49) | CYP19A1ALDH1A1LMNAMAPT | |
| SCHEMBL28923795 | 0.75 | KCNH2 (0.50) | CYP19A1ALDH1A1MEN1LMNAMAPT | |
| SCHEMBL2125302 | 0.75 | CYP19A1 (0.58) | CYP19A1MEN1MAPTKMT2A | |
| SCHEMBL10430003 | 0.75 | CYP19A1 (0.48) | CYP19A1ALDH1A1LMNAMAPT | |
| SCHEMBL6620808 | 0.74 | SIGMAR1 (0.60) | ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL12758951 | 0.73 | HRH3 (0.56) | GPR84ALDH1A1MEN1LMNAMAPT | |
| SCHEMBL6597520 | 0.73 | CYP19A1 (0.51) | CYP19A1ALDH1A1MEN1LMNAMAPT | |
| SCHEMBL7807147 | 0.73 | KDM4E (0.55) | CYP19A1ALDH1A1MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779887-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES HAVING CGMP-PHOSPHODISTERASE INHIBITING ACTIVITY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |