Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.38 |
| ▸ | PTGES | O14684 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799004 | 0.90 | PPARG (0.38) | PPARGPTGESALOX5TSHRFOLH1 | |
| SCHEMBL8798512 | 0.83 | PPARG (0.39) | PPARGPTGESALOX5TSHRFOLH1 | |
| SCHEMBL8799665 | 0.80 | ALDH1A1 (0.38) | FOLH1KMT2AALDH1A1 | |
| SCHEMBL9119381 | 0.80 | CYP4F2 (0.37) | PPARGPTGESALOX5TSHRFOLH1 | |
| SCHEMBL8799424 | 0.79 | MAPT (0.47) | KMT2AL3MBTL1TDP1ALDH1A1KDM4E | |
| SCHEMBL8800391 | 0.79 | LTB4R (0.55) | — | |
| SCHEMBL8463998 | 0.78 | PPARG (0.48) | PPARGPTGESALOX5TSHRFOLH1 | |
| SCHEMBL9121693 | 0.77 | PPARG (0.53) | PPARGPTGESALOX5TSHRFOLH1 | |
| SCHEMBL9119423 | 0.77 | PPARG (0.53) | PPARGPTGESALOX5TSHRFOLH1 | |
| SCHEMBL8464381 | 0.77 | PPARG (0.47) | PPARGPTGESALOX5TSHRFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |