Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799244 | 0.92 | MAPT (0.47) | MAPTLMNARAB9AL3MBTL1KMT2A | |
| SCHEMBL8798867 | 0.89 | FOLH1 (0.46) | MAPTLMNARAB9AKMT2AMEN1 | |
| SCHEMBL8799665 | 0.87 | ALDH1A1 (0.38) | LMNARAB9AKMT2ASMN1; SMN2TP53 | |
| SCHEMBL8800392 | 0.80 | LTB4R (0.50) | — | |
| SCHEMBL8800191 | 0.79 | PPARG (0.38) | MAPTL3MBTL1KMT2AHPGDALDH1A1 | |
| SCHEMBL23434798 | 0.79 | MAPT (0.59) | MAPTLMNARAB9AL3MBTL1KMT2A | |
| SCHEMBL8798512 | 0.78 | PPARG (0.39) | L3MBTL1KMT2ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL8799317 | 0.77 | ALDH1A1 (0.38) | LMNARAB9AKMT2ASMN1; SMN2TP53 | |
| SCHEMBL8799422 | 0.73 | MAPT (0.50) | MAPTLMNARAB9AL3MBTL1KMT2A | |
| SCHEMBL8799643 | 0.73 | CYP4F2 (0.45) | HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |