Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481778 | 0.85 | KDM4E (0.60) | MAPTNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL8474899 | 0.83 | HTT (0.54) | MAPTNPC1RAB9AKDM4EGAA | |
| SCHEMBL1376033 | 0.75 | GSK3A (0.63) | MAPTNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL7724710 | 0.75 | MAPT (0.71) | MAPTNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL2949324 | 0.74 | TARBP2 (0.48) | MAPTNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL5267093 | 0.72 | ALPL (0.59) | MAPTNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL2888912 | 0.71 | MAPT (1.00) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL8476548 | 0.71 | PDE4A (0.64) | MAPTNPC1RAB9AKDM4ETP53 | |
| SCHEMBL16563432 | 0.70 | THRB (0.59) | MAPTNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL10061103 | 0.69 | HDAC3 (0.55) | MAPTNPC1RAB9AL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0796250-A1 | PYRIDAZINONES AS ENDOTHELIN-RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1997-09-24 | — | — | EP | disclosed |
| WO-1997013758-A1 | PYRIDAZINONES AS ENDOTHELIN-RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-04-17 | — | — | WO | disclosed |