Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953211 | 0.68 | CDK4 (0.56) | MAPK1CDK4CCND1L3MBTL1MEN1 | |
| SCHEMBL31447617 | 0.66 | IDO1 (0.33) | ALDH1A1 | |
| SCHEMBL20674467 | 0.66 | IDO1 (0.33) | ALDH1A1 | |
| SCHEMBL7229595 | 0.61 | MAPK1 (1.00) | MAPK1CDK4CCND1L3MBTL1CYP1A2 | |
| SCHEMBL20631787 | 0.61 | PDE4D (0.32) | — | |
| SCHEMBL9526617 | 0.61 | PKM (0.47) | MAPK1CDK4CCND1L3MBTL1MEN1 | |
| SCHEMBL9308949 | 0.58 | MAPK1 (0.78) | MAPK1CDK4CCND1L3MBTL1MEN1 | |
| SCHEMBL11791537 | 0.58 | MAPK1 (0.56) | MAPK1CDK4CCND1L3MBTL1MEN1 | |
| SCHEMBL6476731 | 0.58 | MAPK1 (0.56) | MAPK1CDK4CCND1L3MBTL1MAPK14 | |
| SCHEMBL12670788 | 0.58 | MAPK14 (0.45) | L3MBTL1MAPK14CYP1A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681581-B1 | SUBSTITUTED FUSED PYRAZOLO COMPOUNDS AND THEIR USE AS HERBICIDES | ZENECA LTD (GB) | 1997-09-10 | — | — | EP | disclosed |
| US-5430007-A | Certain herbicidal pyrazolopyridazines | ZENECA LIMITED (GB) | 1995-07-04 | — | — | US | disclosed |
| WO-1994017062-A1 | SUBSTITUTED FUSED PYRAZOLO COMPOUNDS AND THEIR USE AS HERBICIDES | ZENECA LIMITED (GB) | 1994-08-04 | — | — | WO | disclosed |
| US-5300478-A | Herbicides | ZENECA LIMITED (GB) | 1994-04-05 | — | — | US | disclosed |