Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 9/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 1/20 | 0.46 |
| ▸ | CCKAR | P32238 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801061 | 0.90 | FNTA (0.46) | CCKBRKCNH2FNTAFNTBOXTR | |
| SCHEMBL8801183 | 0.86 | FNTA (0.53) | CCKBRKCNH2FNTAFNTBOXTR | |
| SCHEMBL8940414 | 0.86 | FNTA (0.54) | CCKBRKCNH2FNTAFNTBOXTR | |
| SCHEMBL8672551 | 0.81 | CCKBR (0.50) | CCKBRKCNH2FNTAFNTBCCKAR | |
| SCHEMBL9435434 | 0.80 | FNTA (0.43) | CCKBRKCNH2FNTAFNTBOXTR | |
| SCHEMBL8800985 | 0.77 | OXTR (0.54) | CCKBRKCNH2OXTRCCKAR | |
| SCHEMBL8672807 | 0.77 | CCKBR (0.59) | CCKBRKCNH2CCKARPSEN1PSEN2 | |
| SCHEMBL8672565 | 0.76 | CCKBR (0.52) | CCKBRKCNH2FNTAFNTBCCKAR | |
| SCHEMBL15221506 | 0.75 | FNTA (0.56) | CCKBRFNTAFNTBOXTRCCKAR | |
| SCHEMBL8801416 | 0.74 | FNTA (0.64) | CCKBRFNTAFNTBOXTRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | claimed |
| EP-0763537-A2 | Non-peptidyl Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0698015-A1 | PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE | GENENTECH, INC. (US) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | disclosed |