Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9274128 | 0.91 | SMN1; SMN2 (0.36) | ACHEAGTR1SMN1; SMN2AGTR2BRS3 | |
| SCHEMBL8667923 | 0.87 | ACHE (0.39) | ACHEAGTR1AGTR2 | |
| SCHEMBL8802179 | 0.86 | AGTR1 (0.46) | ACHEAGTR1AGTR2BRS3 | |
| SCHEMBL9270036 | 0.80 | AGTR1 (0.38) | ACHEAGTR1AGTR2BRS3 | |
| SCHEMBL8801326 | 0.80 | ACHE (0.45) | ACHEAGTR1AGTR2APLNRPPARG | |
| SCHEMBL9274134 | 0.78 | GAA (0.36) | L3MBTL1BRS3 | |
| SCHEMBL8979815 | 0.76 | BRS3 (0.48) | AGTR1AGTR2PPARGBRS3 | |
| SCHEMBL8979808 | 0.75 | BRS3 (0.48) | AGTR1AGTR2BRS3 | |
| SCHEMBL8979791 | 0.75 | AGTR1 (0.46) | ACHEAGTR1AGTR2APLNRBRS3 | |
| SCHEMBL8979813 | 0.75 | ACHE (0.46) | ACHEAGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680480-B1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | LUSO FARMACO INST (IT) | 1997-07-30 | — | — | EP | disclosed |
| EP-0680480-A1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY. | LUSO FARMACO INST (IT) | 1995-11-08 | — | — | EP | disclosed |
| WO-1994017067-A1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1994-08-04 | — | — | WO | disclosed |