Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | BRS3 | P32247 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9202373 | 0.90 | ACHE (0.39) | AGTR1ACHEAGTR2BDKRB1LTB4R2 | |
| SCHEMBL8979775 | 0.88 | AGTR1 (0.45) | AGTR1ACHEAGTR2BDKRB1LTB4R2 | |
| SCHEMBL8979827 | 0.88 | AGTR1 (0.44) | AGTR1ACHEAGTR2BDKRB1LTB4R2 | |
| SCHEMBL8802179 | 0.87 | AGTR1 (0.46) | AGTR1ACHEAGTR2BDKRB1LTB4R2 | |
| SCHEMBL8672154 | 0.87 | ACHE (0.47) | AGTR1ACHEAGTR2BDKRB1BRS3 | |
| SCHEMBL8668602 | 0.86 | BDKRB1 (0.43) | AGTR1ACHEAGTR2BDKRB1LTB4R2 | |
| SCHEMBL8979791 | 0.86 | AGTR1 (0.46) | AGTR1ACHEAGTR2BDKRB1LTB4R2 | |
| SCHEMBL8979758 | 0.85 | AGTR1 (0.49) | AGTR1ACHEAGTR2BDKRB1LTB4R2 | |
| SCHEMBL8979872 | 0.85 | AGTR1 (0.49) | AGTR1ACHEAGTR2BDKRB1LTB4R2 | |
| SCHEMBL8979887 | 0.85 | AGTR1 (0.45) | AGTR1ACHEAGTR2BDKRB1LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680480-B1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | LUSO FARMACO INST (IT) | 1997-07-30 | — | — | EP | disclosed |
| WO-1994017067-A1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1994-08-04 | — | — | WO | disclosed |