Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800895 | 0.86 | KDM4E (0.47) | HRH4HRH3KDM4EALDH1A1MEN1 | |
| SCHEMBL8801559 | 0.84 | ALDH1A1 (0.39) | HRH4HRH3KDM4EALDH1A1MEN1 | |
| Trifluoroacetic Acid SCHEMBL8801749 | 0.83 | HRH4 (0.49) | HRH4HRH3KDM4EALDH1A1MEN1 | |
| SCHEMBL9317415 | 0.81 | PRKAB2 (0.47) | HRH4HRH3KDM4EALDH1A1MEN1 | |
| SCHEMBL8801538 | 0.80 | PARP1 (0.47) | HRH4HRH3KDM4EALDH1A1MEN1 | |
| Maleic Acid SCHEMBL8801778 | 0.75 | KDM4E (0.52) | HRH4HRH3KDM4EALDH1A1MEN1 | |
| Fumaric Acid SCHEMBL8801790 | 0.75 | KDM4E (0.52) | HRH4HRH3KDM4EALDH1A1MEN1 | |
| SCHEMBL16517620 | 0.74 | ALDH1A1 (0.46) | KDM4EALDH1A1MEN1KMT2AFGFR1 | |
| SCHEMBL8801593 | 0.73 | KDM4E (0.41) | HRH4HRH3KDM4EALDH1A1MEN1 | |
| SCHEMBL25343179 | 0.73 | PTGER4 (0.40) | HRH4ALDH1A1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0627432-B1 | 6-Piperazinyl-1H-pyrazolo [3,4-b]pyridine-3-carboxylic Acids, Esters, Amides and related compounds, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0627432-A1 | 6-Piperazinyl-1H-pyrazolo [3,4-b]pyridine-3-carboxylic Acids, Esters, Amides andrelated compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5300498-A | Treating depression, obsessive compulsive disorder | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-04-05 | — | — | US | disclosed |