Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 14/20 | 0.62 |
| ▸ | MAOB | P27338 | 14/20 | 0.62 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.55 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8144365 | 0.93 | MAOA (0.64) | MAOAMAOBCYSLTR1GPBAR1 | |
| SCHEMBL8019618 | 0.91 | MAOA (0.62) | MAOAMAOBPDE10AALOX5APCYSLTR1 | |
| SCHEMBL9490729 | 0.83 | PDE10A (0.52) | PDE10AALOX5APCYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL9490591 | 0.81 | MAOB (0.68) | MAOAMAOB | |
| SCHEMBL8140420 | 0.80 | PDE10A (0.49) | MAOAMAOBPDE10ACYSLTR1CYSLTR2 | |
| SCHEMBL10726171 | 0.79 | PDE10A (0.55) | PDE10AALOX5APCYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8129843 | 0.79 | CYSLTR1 (0.53) | PDE10ACYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL7483348 | 0.78 | PDE10A (0.60) | PDE10AALOX5APCYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL226640 | 0.77 | MAOB (1.00) | MAOAMAOB | |
| SCHEMBL8029278 | 0.77 | GRM5 (0.54) | MAOBPDE10ACYSLTR1CYSLTR2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5512581-A | ANTIINFLAMMATORY AGENT | ABBOTT LABORATORIES (US) | 1996-04-30 | — | — | US | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |