Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.51 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801952 | 0.83 | MAOA (0.62) | PDE10AALOX5APCYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL9490302 | 0.82 | MAOA (0.54) | — | |
| SCHEMBL9489485 | 0.79 | MAOA (0.66) | — | |
| SCHEMBL8144365 | 0.77 | MAOA (0.64) | CYSLTR1GPBAR1 | |
| SCHEMBL8019618 | 0.76 | MAOA (0.62) | PDE10AALOX5APCYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10726171 | 0.76 | PDE10A (0.55) | PDE10AALOX5APCYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL7483348 | 0.75 | PDE10A (0.60) | PDE10AALOX5APCYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8801596 | 0.75 | PDE10A (0.53) | PDE10AALOX5APCYSLTR1GPBAR1CYSLTR2 | |
| Hydrochloric Acid SCHEMBL7532657 | 0.74 | PDE10A (0.58) | PDE10AALOX5APCYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10512475 | 0.74 | PDE10A (0.77) | PDE10ACYSLTR1GPBAR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0522000-A1 | 5-LIPOXYGENASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-01-13 | — | — | EP | disclosed |
| WO-1991014674-A2 | 5-LIPOXYGENASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-03 | — | — | WO | disclosed |