Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 16/20 | 0.49 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802153 | 0.88 | ATR (0.46) | ATRTLR9GSK3BPRKDCNOS1 | |
| SCHEMBL8802240 | 0.73 | XDH (0.37) | — | |
| SCHEMBL32688927 | 0.72 | ATR (0.66) | ATRTLR9PRKDC | |
| SCHEMBL6701248 | 0.72 | ATR (0.66) | ATRTLR9PRKDC | |
| SCHEMBL8801248 | 0.71 | ATR (0.41) | ATRTLR9PRKDCNOS1 | |
| SCHEMBL12489014 | 0.68 | ATR (0.56) | ATRTLR9PRKDCNOS1 | |
| SCHEMBL29519952 | 0.68 | ATR (0.56) | ATRTLR9PRKDCNOS1 | |
| SCHEMBL8801678 | 0.67 | ATR (0.40) | ATRTLR9GSK3BATMNOS1 | |
| SCHEMBL87574 | 0.66 | CKS1B (0.55) | ATRTLR9 | |
| SCHEMBL29886432 | 0.66 | ATR (0.57) | ATRPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0580916-B1 | N(1) substituted pyrazino [2,3-c]-1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals | PRODESFARMA SA (ES) | 1997-03-05 | — | — | EP | claimed |