SCHEMBL8802452

SCHEMBL8802452

CO[C@@H]1CN(c2ccc3c(=O)c(C=O)cn(-c4nccs4)c3n2)C[C@H]1NCC(=O)OC(C)(C)C

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RET P07949 2/20 0.31
CPB2 Q96IY4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8802441 1.00 RET (0.31) RETCPB2
SCHEMBL8802444 1.00 RET (0.31) RETCPB2
SCHEMBL7835607 0.89 HTR3A (0.32) RETCPB2
SCHEMBL7835604 0.89 HTR3A (0.32) RETCPB2
SCHEMBL7835615 0.89 HTR3A (0.32) RETCPB2
SCHEMBL7832312 0.87 OPRK1 (0.34) RET
SCHEMBL7832305 0.87 OPRK1 (0.34) RET
SCHEMBL7832308 0.87 OPRK1 (0.34) RET
SCHEMBL763215 0.86 OPRK1 (0.31)
Hydrochloric Acid SCHEMBL7835735 0.86 OPRK1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787726-A1 NOVEL COMPOUND, PROCESS FOR PRODUCING THE SAME, AND ANTITUMOR AGENT DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1997-08-06 EP disclosed