Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800858 | 0.75 | ATR (0.41) | ADORA2ARAB9ANPC1 | |
| SCHEMBL8802240 | 0.71 | XDH (0.37) | XDHKDM4EHPGDSMN1; SMN2ADORA2A | |
| SCHEMBL8800607 | 0.69 | — | — | |
| SCHEMBL562413 | 0.69 | MAPK13 (0.43) | KDM4EHPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8800991 | 0.69 | ADORA2A (0.38) | XDHKDM4EHPGDADORA2AADORA1 | |
| SCHEMBL19829410 | 0.68 | CSNK1A1 (0.52) | XDHKDM4EHPGDSMN1; SMN2ADORA2A | |
| SCHEMBL10205869 | 0.67 | TDP1 (0.54) | KDM4EHPGDSMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL10945797 | 0.67 | KDM4E (0.54) | KDM4EHPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13515891 | 0.63 | KDM4E (0.50) | KDM4EHPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8800740 | 0.63 | ADORA2A (0.40) | XDHKDM4EHPGDSMN1; SMN2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0580916-B1 | N(1) substituted pyrazino [2,3-c]-1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals | PRODESFARMA SA (ES) | 1997-03-05 | — | — | EP | claimed |
| EP-0580916-A1 | N(1) substituted pyrazino 2,3-c -1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals | PRODESFARMA, S.A. (ES) | 1994-02-02 | — | — | EP | claimed |
| EP-0580916-B1 | N(1) substituted pyrazino [2,3-c]-1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals | PRODESFARMA SA (ES) | 1997-03-05 | — | — | EP | disclosed |
| US-5580869-A | DIURETIC, BRONCHODILATOR,AND PLATELET ANTIAGGREGATION ACTIVITY | PRODESFARMA, S.A. (ES) | 1996-12-03 | — | — | US | disclosed |
| EP-0580916-A1 | N(1) substituted pyrazino 2,3-c -1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals | PRODESFARMA, S.A. (ES) | 1994-02-02 | — | — | EP | disclosed |