Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 6/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801248 | 0.89 | ATR (0.41) | ATRNOS1TLR9PRKDCMAPK1 | |
| SCHEMBL8803154 | 0.75 | XDH (0.38) | NPC1RAB9AADORA2A | |
| SCHEMBL8802153 | 0.71 | ATR (0.46) | ATRNOS1TLR9PRKDCMAPK1 | |
| SCHEMBL562413 | 0.69 | MAPK13 (0.43) | NPC1RAB9A | |
| SCHEMBL8800717 | 0.68 | NEK2 (0.37) | ATRNOS1TLR9PRKDCMAPK1 | |
| SCHEMBL8800607 | 0.66 | — | — | |
| SCHEMBL8800843 | 0.65 | ATR (0.38) | ATRNOS1TLR9PRKDCNEK2 | |
| SCHEMBL87574 | 0.64 | CKS1B (0.55) | ATRTLR9MAPK1L3MBTL1NPC1 | |
| SCHEMBL12322083 | 0.64 | MAP4K4 (0.36) | ADORA2A | |
| SCHEMBL6701248 | 0.63 | ATR (0.66) | ATRTLR9PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0580916-B1 | N(1) substituted pyrazino [2,3-c]-1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals | PRODESFARMA SA (ES) | 1997-03-05 | — | — | EP | claimed |
| EP-0580916-A1 | N(1) substituted pyrazino 2,3-c -1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals | PRODESFARMA, S.A. (ES) | 1994-02-02 | — | — | EP | claimed |
| EP-0580916-B1 | N(1) substituted pyrazino [2,3-c]-1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals | PRODESFARMA SA (ES) | 1997-03-05 | — | — | EP | disclosed |
| US-5580869-A | DIURETIC, BRONCHODILATOR,AND PLATELET ANTIAGGREGATION ACTIVITY | PRODESFARMA, S.A. (ES) | 1996-12-03 | — | — | US | disclosed |
| EP-0580916-A1 | N(1) substituted pyrazino 2,3-c -1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals | PRODESFARMA, S.A. (ES) | 1994-02-02 | — | — | EP | disclosed |