Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.42 |
| ▸ | GAA | P10253 | 13/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.42 |
| ▸ | RAB9A | P51151 | 9/20 | 0.42 |
| ▸ | NPC1 | O15118 | 9/20 | 0.42 |
| ▸ | MEN1 | O00255 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.42 |
| ▸ | GFER | P55789 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23657817 | 0.72 | MAPT (0.58) | MAPTGAAKMT2ARAB9ANPC1 | |
| SCHEMBL880213 | 0.69 | MAPT (0.61) | MAPTGAAKMT2ARAB9ANPC1 | |
| SCHEMBL880417 | 0.68 | MAPT (0.83) | MAPTGAAKMT2ARAB9ANPC1 | |
| SCHEMBL4151151 | 0.68 | HRH4 (0.47) | KMT2ARAB9ANPC1MEN1SMN1; SMN2 | |
| SCHEMBL9891793 | 0.67 | FFAR2 (0.56) | KMT2ARAB9ANPC1MEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28371344 | 0.66 | RAB9A (0.48) | KMT2ARAB9ANPC1MEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4159988 | 0.66 | RAB9A (0.48) | KMT2ARAB9ANPC1MEN1SMN1; SMN2 | |
| SCHEMBL11171719 | 0.66 | NPC1 (0.55) | MAPTKMT2ARAB9ANPC1MEN1 | |
| SCHEMBL9893032 | 0.65 | LMNA (0.63) | KMT2ARAB9ANPC1MEN1TDP1 | |
| SCHEMBL16342365 | 0.65 | RAB9A (0.45) | MAPTGAAKMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |