Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2351809 | 0.89 | TAAR1 (0.50) | TAAR1MEN1KMT2AMAOBMIF | |
| SCHEMBL8802944 | 0.80 | MEN1 (0.47) | TAAR1MEN1KMT2AMAOB | |
| SCHEMBL3725188 | 0.78 | TAAR1 (0.44) | TAAR1KMT2AMAOBMIFIDO1 | |
| SCHEMBL8803735 | 0.77 | MEN1 (0.47) | TAAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL19347555 | 0.77 | ALOX5 (0.51) | TAAR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8804638 | 0.77 | MEN1 (0.47) | TAAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL8804058 | 0.77 | KMT2A (0.47) | TAAR1MEN1KMT2AHDAC1HDAC8 | |
| SCHEMBL51024 | 0.76 | MEN1 (0.69) | TAAR1MEN1KMT2A | |
| SCHEMBL7851777 | 0.75 | HDAC1 (0.41) | TAAR1HDAC1HDAC8MAOBGAA | |
| SCHEMBL24258335 | 0.75 | MAOB (0.50) | TAAR1HDAC1HDAC8MAOBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0492474-B1 | 1,3-Dioxolane derivatives as cholesterol-lowering agents | SYNTEX INC (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5158949-A | 1,3-DIOXOLANE DERIVATIVES AS CHOLESTEROL-LOWERING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0492474-A1 | 1,3-Dioxolane derivatives as cholesterol-lowering agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-01 | — | — | EP | disclosed |