Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.42 |
| ▸ | RPS6KA1 | Q15418 | 4/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13522411 | 0.84 | HTT (0.76) | HTTLMNATSHRGAAKMT2A | |
| SCHEMBL880422 | 0.84 | MAPT (0.47) | HTTLMNATSHRGAAGPBAR1 | |
| SCHEMBL31633556 | 0.73 | DDB1 (0.69) | LMNATSHRGAAKMT2ADDB1 | |
| SCHEMBL17478091 | 0.72 | GPBAR1 (0.59) | HTTTSHRGAAKMT2AGPBAR1 | |
| SCHEMBL880375 | 0.71 | HTT (0.78) | HTTLMNATSHRGAAGPBAR1 | |
| SCHEMBL13522409 | 0.71 | HTT (0.64) | HTTTSHRGAAGPBAR1TP53 | |
| SCHEMBL14029127 | 0.70 | HTT (0.67) | HTTLMNATSHRGAAGPBAR1 | |
| SCHEMBL880259 | 0.70 | IDO1 (0.60) | LMNATSHRGAAKMT2AGPBAR1 | |
| SCHEMBL3342133 | 0.70 | LMNA (0.58) | HTTLMNAGAAGPBAR1TP53 | |
| SCHEMBL3888823 | 0.70 | GPBAR1 (0.65) | HTTLMNATSHRGAAGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |